Who to start and who to sit? It’s the one question you need to answer right in order to do well in this crazy game of fantasy football. You won’t get it right every time but at Bruno Boys we help you work through those tougher decisions to make an informed and confident starting lineup.

Our Running Backs Starts and Sits look specifically at the line that separates RB2s and RB3s. Which ones are legit RB2 starts and which ones are better projected as a flex? We also consider PPR vs. standard, sleeper picks and streaming options too.

We will rarely cover studs unless it’s a sit recommendation based on matchup or we want to make note of a significant angle in the Quick Hits section at the end. Injuries happen too, which affects other players’ fantasy outlook. Lastly, bye weeks are a factor now.

Here are the Week 6 Fantasy Football Running Backs to Start.

Zack Moss, Buffalo Bills at Tennessee Titans

We have been banging the Zack Moss drum all season long and hopefully you’ve been listening. Aside from that Week 1 inactive hiccup, Moss has been active averaging 11.5 carries and 2.0 receptions off 2.5 targets. He has turned that into 46.0 average rushing yards, 23.5 receiving yards and 1.0 touchdowns per game. He continues to stretch out the gap between him and Devin Singletary, who appears to do little whenever he out-touches Moss.

Moss will see the Titans who were torched by Jacksonville’s James Robinson. It was the fifth time the Titans have allowed a running back to reach double-digits. The Bills run to set up the pass, but they’ll have the luxury to flip the switch with Moss in the red zone.