Who to start and who to sit? That’s the question that plagues everyone who plays fantasy football on a weekly basis?

Honestly, it’s the one question you need to answer right in order to do well in this crazy game of fantasy. Will you get it right all the time? No, because football will surprise, especially if you buy into the adage: On any given Sunday, any team can beat any other team. But relax, we’re here to help you work through those decisions with as much information as you need to be confident in a decision you can stand by.

Running backs are the life force of every NFL offense, but whether you start them or leave them on the bench depends on how many touches they get, where they get those touches and how well they pick up the blitz. When and where do your backs get to touch the football? What’s the state of their team’s passing game? Do you have a feature back or a specialist? It’s the difference between an RB2 and a Flex, a PPR starter and a non-PPR grinder, or simply a start or a sit.

Here are the Week 5 Fantasy Football Running Backs to Start.

Darrell Henderson, Los Angeles Rams at Seattle Seahawks

If you think that the Seahawks’ run defense only got obliterated by Derrick Henry, think again. Dalvin Cook’s backup, Alexander Mattison rushed for over 100 yards and caught six passes for 59 yards in his absence. Jonathan Taylor and Nyheim Hines combined for 198 total yards against the Seahawks. And rookie Trey Sermon rushed 19 times for 89 yards against them. With Henderson seemingly healthy for Week 5, the time to go all in on Henderson to potentially rise up and get RB1 numbers is right now.