New Orleans Saints vs. San Francisco 49ers
The Saints defense is no doubt the strength of this iteration of the team. They’ve held the fort when Drew Brees was out, but this will be a tough matchup as only three opposing defenses have scored in double digits against them. Five of their last six opponents failed to score more than 7.0 fantasy points as it has been tough to get turnovers and more than 2.0 sacks on Jimmy Garoppolo. New Orleans is a tough place to play but this will be a big test for both heading into the playoffs.